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Amphetamine is known to inhibit monoamine oxidase, whereas the flexibility of amphetamine and its metabolites to inhibit several P450 isozymes and also other enzymes hasn't been sufficiently elucidated. In vitro experiments with human microsomes suggest minor inhibition of CYP2D6 by amphetamine and minimal inhibition of CYP1A2, 2D6, and 3A4 by one